Current Issue : October-December Volume : 2017 Issue Number : 4 Articles : 3 Articles
The present study was designed to evaluate effects of Clitoria ternatea extract could affect ethanol withdrawal-induced complication like memory dysfunction in mice. This study investigated the role of Clitoria ternatea extract (100 and 200 mg/kg) against melatonin (10 mg/kg) on ethanol withdrawal induced complications using the novel object recognition test (NORT). Swiss albino mice received an ethanol-containing liquid diet (600 kcal/l) for 10 days and were tested for withdrawal signs and symptoms after termination of the diet. Clitoria ternatea extract (100 and 200 mg/kg) showed increase in open arm entries, novel object exploration ratio and decrease in close arm entries than ethanol control mice. EECT also possess anti-oxidant action. The histopathological studies also signified that the cognitive impairment in mice was mainly due to degeneration of neurons in functional zones of hippocampus that controls the memory and related behavior....
Tephrosia maxima (L.) Pers (Leguminosae (Fabaceae)), is an herbaceous climber that has been generally utilized in Indian traditional medicine for the treatment of different central nervous system (CNS) disorders. Nevertheless, the available scientific information about this species is rare and there are no reports identified with its conceivable impact on the CNS. In this work, the effects of ethanolic extract of Tephrosia maxima (L.) Pers (TMP) were assessed in rats utilizing behavioral tests sensitive to clinically effective antidepressant and anxiolytic effects compounds. The extract (200 and 400 mg/kg), administered intraperitoneally, was able to decrease the immobility time of rats dose‐dependently when subjected to both tail suspension and forced swim tests for antidepressant activity. Anxiolytic effect to determine by elevated pluse maze test and actophotometer test models and the effects are comparable to that of standard drugs i.e., Diazepam (20 mg/kg). Neither the extracts of TMP and diazepam at the doses tested, produced significant effects on locomotor activity when subjected to open field behavioral test. These results demonstrated that TMP had specifically antidepressant effects in-vivo. In conclusion, the present study recommended that TMP extracts possessed potential antidepressant and anxiolytic effects which could be of therapeutic interest for using in the treatment of patients with depressive disorders....
Stone formation in the kidney is one of the oldest and most wide spread diseases known to man. This study was to evaluate the anti-urolithiatic activity of Raphnus sativus.L and Viscum articulatum Burm.F with that of standard drug cystone. This study proved fresh juice, aqueous and alcoholic extract of both plants executed on generated calcium oxalate crystals by homogenous precipitation method for in-vitro anti-urolithiatic activity. The exiting fact came out of the study is that the fresh juice, aqueous and alcoholic extract of Raphnus sativus / Viscum articulatum showed significantly (p<0.001) increased % dissolution of calcium oxalate levels when compared with control and also equal potential as compared to standard drug cystone in dissolving the artificial stone crystals even in the crude form. Thus the present study provides a scientific rationale for the traditional use of this plant in the management of urolithiasis....
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